Saturday , September 25 2021

High cholesterol in middle age is associated with an increased risk of dementia, according to research



High cholesterol in middle age is associated with an increased risk of dementia and Alzheimer’s more than a decade later, according to research

  • The study looked at 1.8 million adults over the age of 40 with a follow-up period of up to 23 years.
  • Of the 953,635 people who had elevated levels of low-density lipoprotein cholesterol, 2.3 percent or 21,602 continued to be diagnosed with the disease
  • While elevated total cholesterol levels were also associated with increased risk, this link was weaker suggesting that it was largely due to LDL
  • The study was led by the London School of Hygiene & Tropical Medicine

High cholesterol in middle age is associated with an increased risk of dementia and Alzheimer’s more than a decade later, according to research.

The study looked at 1.8 million adults over the age of 40 with a follow-up period of up to 23 years or up to the diagnosis of dementia.

Of the 953,635 people who had elevated levels of low-density lipoprotein cholesterol, 2.3 percent or 21,602 continued to be diagnosed with the disease.

The study looked at 1.8 million adults over the age of 40 with a follow-up period of up to 23 years or up to the diagnosis of dementia (photo archive)

The study looked at 1.8 million adults over the age of 40 with a follow-up period of up to 23 years or up to the diagnosis of dementia (photo archive)

Of the 953,635 people who had elevated levels of low-density lipoprotein cholesterol, 2.3 percent or 21,602 continued to be diagnosed with the disease (photo file)

Of the 953,635 people who had elevated levels of low-density lipoprotein cholesterol, 2.3% or 21,602 continued to be diagnosed with the disease (photo file)

While elevated total cholesterol levels were also associated with increased risk, this relationship was weaker suggesting that it was largely due to LDL.

The head of the study, Dr. Nawab Qizilbash, of OXON Epidemiology, said: “Long-term follow-up studies are needed to assess whether the benefits of LDL cholesterol-lowering interventions may reduce the risk of dementia or Alzheimer’s disease.”

The study, published in The Lancet Healthy Longevity, is considered to be the largest of its kind and provides the strongest evidence for a link between blood cholesterol and dementia and Alzheimer’s disease.

He was the head of the School of Health and Tropical Medicine in London with Tsukuba University in Japan and OXON Epidemiology.


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