Wednesday , August 4 2021

New research aims to help improve the intake of the hepatitis C test

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New research published in Scientific reports shows that persistent fears of HIV infection may affect HCV intake.

HCV infects the liver. If left untreated, it can cause serious and potentially life-threatening liver damage for many years. Today, with the help of modern therapies it is usually possible to cure the infection and most people with it will have a normal life expectancy.

It is estimated that 1% of the world's population is chronically infected with HCV. The World Health Organization (WHO) has set the global goal of eliminating HCV infection as a major threat to public health by 2030. In the UK (UK), about 214,000 people live with chronic HCV infection. The elimination of hepatitis C as a threat to public health requires a better understanding of how the intake of tests increases.


Researchers at the University's Institute of Infection and World Health, headed by Professor Anna Gereti, conducted screening tests (POCT) for a current HCV infection in an Emergency Department of the city and assessed the effect on HIV-related HIV intake.

POCT or bed tests are medical diagnostic tests at the point of care or near the point of care, that is, at the time and place of patient care instead of sending a blood sample to the laboratory and then waiting for the results.

Over four months, all adults who followed ED with minor injuries were first asked to complete an anonymous questionnaire, then in alternating circles they were invited to perform a hematocrit test that would detect HCV and / or HCV and HIV.

Reduced intake

Questionnaires received 94.8% (814/859) and 39.8% (324/814), including 211 HCV and 113 HCV + HIV, were received.

Researchers have found that HCV-related testing associated with the HIV test significantly reduces intake after adaptation for age and previous HCV testing.

The prevalence of HCV was 1/324 and no participant tested positive for HIV.

Based on the postal codes obtained from the questionnaires submitted, 56.2% of the participants lived in the most deprived neighborhoods of England.

Continued fears

Professor Geretti said: "Our study found that the POCT HCV with tear gas test was technically feasible and is suitable for placement in places where people with undiagnosed hepatitis C may appear to be treated.

HCV POCT uptake was moderate and the associated HIV screening offer showed that it had a detrimental effect on the acceptance in this low prevalence population.

"The study shows that persistent fears about HIV infection can affect the behavior of the tests." The findings have implications for the design of HCV detection programs in the future, we need to understand how to overcome the apparent obstacle.

Explore further:
Public health care-primary care has high intake, does not detect hidden hepatitis C.

More information:
Anna Maria Geretti et al. Check Point of Care for a Current Hepatitis C Virus Infection: Effect on Intake of a Concurrent Supply of HIV Screening, Scientific reports (2018). DOI: 10.1038 / s41598-018-33172-w

Scientific reports

Provided by:
University of Liverpool

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